How Alzheimer’s Risk Gene APOE4 Disrupts Myelination
Headline from Geneng News
Study linked the APOE4 gene with suppression of Wnt signaling in the oligodendrocyte cells that provide neurons with their fatty myelin insulation, and also demonstrated a potential approach to preventing disruption of myelination.
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One of the main ways that the APOE4 gene variant, the biggest genetic risk factor for late-onset Alzheimer's disease, undermines brain circuit function is by disrupting the process of insulating neurons with a fatty sheath that optimizes their electrical transmission.
Study linked the APOE4 gene with suppression of Wnt signaling in the oligodendrocyte cells that provide neurons with their fatty myelin insulation, and also demonstrated a potential approach to preventing disruption of myelination.
How Alzheimer’s Risk Gene APOE4 Disrupts Myelination | Since Then
