Coverage dated October 19, 2026 to October 24, 2026

Diagnostic uncertainty: Why losing a diagnosis can be as difficult as receiving one

Headline from MedicalXpress

When actor Christina Applegate revealed that she had been misdiagnosed with multiple sclerosis (MS), she described the experience as "very unnerving" and "really confusing."

MedicalXpress's own description from its feed. We collect headlines and these descriptions, not full articles; read the original reporting below.

Reports & sources

106 articles, oldest first.

  1. NBC Chicago

    Christina Applegate says her MS was misdiagnosed. A neurologist explains why misdiagnosis is common (opens NBC Chicago)

    Published

    NBC Chicago's feed description

    Actor Christina Applegate announced Tuesday that she had been misdiagnosed with multiple sclerosis, a condition she believed she had for more than five years. Applegate revealed the misdiagnosis on the latest episode of her podcast, recalling that a doctor recently told her: “Congratulations.

  2. NBC Los Angeles

    Christina Applegate says she was misdiagnosed with multiple sclerosis (opens NBC Los Angeles)

    Published

    NBC Los Angeles's feed description

    Christina Applegate poses for photos with her Hollywood Walk of Fame star in Hollywood, California, on Nov. 14, 2022.

  3. Independent Journal Review

    Christina Applegate says prior MS diagnosis was mistaken (opens Independent Journal Review)

    Published

    Independent Journal Review's feed description

    Christina Applegate said she was told by her doctor that she had been misdiagnosed with multiple sclerosis, the condition she had publicly discussed since 2021. She remains severely symptomatic and says doctors are investigating the cause, leaving her uncertain and distressed.

  4. Variety

    Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’ (opens Variety)

    Published

    Variety's feed description

    Christina Applegate returned to her podcast, “MeSsy,” on Tuesday with some shocking news: She was misdiagnosed with multiple sclerosis. After taking a break from the podcast for seven months due to her health, Applegate tearfully shared the revelation, recalling that her doctor “came into my room an…

  5. New York Post

    Christina Applegate reveals MS misdiagnosis in shocking health update: ‘I lost everything’ (opens New York Post)

    Published

    New York Post's feed description

    “You don’t get misdiagnosed and then all of the sudden I’m better,” the actress said.

  6. ABC 7 San Francisco

    Christina Applegate says she was misdiagnosed with MS (opens ABC 7 San Francisco)

    Published

    ABC 7 San Francisco's feed description

    Christina Applegate says she was misdiagnosed with the neurological and autoimmune disorder multiple sclerosis.

  7. CBS News

    Christina Applegate reveals she was misdiagnosed with MS (opens CBS News)

    Published

    CBS News's feed description

    Christina Applegate said on her MeSsy podcast that her doctor recently revealed she did not have multiple sclerosis.

  8. The Hollywood Reporter

    Christina Applegate Reveals She Was Misdiagnosed and Does Not Have MS: “I Haven’t Gotten Better … I’m Back at Square One” (opens The Hollywood Reporter)

    Published

    The Hollywood Reporter's feed description

    Applegate returned to the podcast she co-hosts with Jamie Lynn-Sigler to reveal the health news that is sending her for a loop: "You don't get misdiagnosed and then all of a sudden, I'm better. I haven't gotten better," she shares. "If anything, I've gotten worse in some ways."

  9. Phl17

    Christina Applegate says she was misdiagnosed with MS: 'I haven't gotten better' (opens Phl17)

    Published

    Phl17's feed description

    Christina Applegate has revealed that she was misdiagnosed with multiple sclerosis, putting her "back at square one."

  10. The Guardian

    Actor Christina Applegate reveals she was misdiagnosed with multiple sclerosis (opens The Guardian)

    Published

    The Guardian's feed description

    The Married … with Children actor says the news is ‘unnerving’ and ‘really confusing’ Sign up for the Breaking News US newsletter email After becoming a prominent advocate for multiple sclerosis awareness and chronicling her struggles in an emotional memoir published in March, the Emmy-winning actor…

  11. Fox News

    Christina Applegate says she was misdiagnosed with MS and is now 'back at square one' (opens Fox News)

    Published

    Fox News's feed description

    Christina Applegate fought back tears discussing her MS misdiagnosis, saying the news brought confusion, depression and no relief from symptoms.

  12. Breitbart News

    Video: Christina Applegate Says She was Misdiagnosed with Multiple Sclerosis (opens Breitbart News)

    Published

    Breitbart News's feed description

    Actress Christina Applegate revealed Tuesday she was previously misdiagnosed with multiple sclerosis (MS), the neurological and autoimmune disorder.

  13. Rolling Stone

    Christina Applegate Says She Was Misdiagnosed With Multiple Sclerosis: ‘It’s Very Confusing’ (opens Rolling Stone)

    Published

    Rolling Stone's feed description

    "You don't get misdiagnosed and then all of the sudden I'm better," actress says on MeSsy podcast

  14. Deadline

    Christina Applegate Reveals MS Misdiagnosis: “I Am Back At Square One” (opens Deadline)

    Published

    Deadline's feed description

    Christina Applegate, diagnosed with multiple sclerosis back in 2021 and has become a leading advocate for people coping with the disease, revealed shocking news today: She was misdiagnosed and does not in fact have MS.

  15. BBC News

    Christina Applegate says she was wrongfully diagnosed with MS (opens BBC News)

    Published

    BBC News's feed description

    She said in a Tuesday release of her Messy podcast that she was not happy about the new information and her symptoms have only "gotten worse".

  16. WHDH Boston

    Actress Christina Applegate announces she was misdiagnosed with multiple sclerosis (opens WHDH Boston)

    Published

    WHDH Boston's feed description

    Actress Christina Applegate announced that she was misdiagnosed and does not have multiple sclerosis (MS). Applegate made the announcement on her podcast which was released...

  17. New York Post

    Christina Applegate details scary health decline in wake of MS misdiagnosis: ‘I’ve gotten worse’ (opens New York Post)

    Published

    New York Post's feed description

    "I’m back at square one where I don’t know what’s going on with me," the actress told podcast listeners.

  18. Philadelphia Inquirer

    Christina Applegate says her doctor told her she was misdiagnosed with MS (opens Philadelphia Inquirer)

    Published

    Philadelphia Inquirer's feed description

    Christina Applegate has revealed her doctor says she was misdiagnosed with multiple sclerosis

  19. KESQ Palm Springs

    Christina Applegate, a leading MS advocate, says doctors found she doesn’t have the disease after all (opens KESQ Palm Springs)

    Published

    KESQ Palm Springs's feed description

    By Lisa Respers France, CNN (CNN) — Since 2021, Christina Applegate has been one of the most famous advocates for living with multiple sclerosis. Now she says she has discovered that she doesn’t actually have the disease.

  20. Gizmodo

    Christina Applegate Was Misdiagnosed With Multiple Sclerosis. It Happens More Often Than You’d Think (opens Gizmodo)

    Published

    Gizmodo's feed description

    A substantial percentage of people initially diagnosed with MS later turn out to not have it, research has shown.

  21. KYMA Yuma

    Actress Christina Applegate says she was misdiagnosed with MS (opens KYMA Yuma)

    Published

    KYMA Yuma's feed description

    On the latest episode of her podcast, the Emmy nominee tearfully recalled being told by a doctor recently, "Congratulations. You don't have MS."

  22. UPI

    Christina Applegate 'back at square one' after MS misdiagnosis (opens UPI)

    Published

    UPI's feed description

    Christina Applegate said on her "MeSsy" podcast with Jamie-Lynn Sigler that she recently learned she was misdiagnosed with multiple sclerosis.

  23. Newsweek

    MS Symptoms Explained as Christina Applegate Shares Misdiagnosis (opens Newsweek)

    Published

    Newsweek's feed description

    The actress said she felt she had "let everybody down" after she became a prominent public voice for MS.

  24. New York Post

    Christina Applegate’s next steps towards finding cause of worsening health issues revealed after incorrect MS diagnosis (opens New York Post)

    Published

    New York Post's feed description

    "Up to 1 in 5 patients diagnosed with MS may not actually have MS but a different condition," Dr. Elena Grebenciucova told The Post. "Symptoms of MS are not unique to MS."

  25. Revolver News

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